Mr. J. van Boxtel, MSc
Stromal Vascular Fraction (SVF) as a (adjunctive) treatment in woundhealing.
Stromal vascular fraction contains many cells but foremost contains adipose tissue derived stem cells (ASCs). ASCs have shown to speed up wound healing. (tissue) SVF, where intercellular connections along with the extracellular matrix (ECM) are intact, can induce angiogenesis and reduce inflammation. Processes that contribute to wound healing.
Maybe SVF can prove to be an adjunctive treatment when treating chronic (diabetic) wounds?
This presentation will give an overview of novel insights of treating wounds with fat.
Drs. Ron Legerstee
Wound healing and its detriments: it is all about microbiology.
A thoughtful quote of Majno & Joris (1) concerning wound healing is ‘’The process of healing is powerfully programmed and very difficult to obstruct, but it has its enemies”. These enemies are few, namely microbes and damage. Cells respond accordingly by producing PAMPS or DAMPS respectively. These inflammasomes underpin the importance of what we already know.
Fred Vermolen, Associate Professor in Applied Mathematics
Mathematical adventures in modelling post-damage skin behavior.
We present and discuss some of the available mathematical models for the evolution of post-wounded skin. Next to the question how skin evolves over time after wounding, we are interested in the likelihood that actual complications such as hypertrophic scarring or contractures occur. The talk will be accessible for non-mathematicians and aims at presenting the possibilities and limitations of mathematical modelling in the context of skin injury.
Nicole Spruijt, Arts Da Vinci Kliniek
Stratification of chronic and complex wounds according to healing characteristics: a retrospective study.
Wound risk-stratified analyses are clinically relevant as they can assist in identifying hard-to-heal wounds. Using two clinical wound variables, diagnosis and duration, stratification categories were identified with significant associations with wound healing outcomes in a cohort of 540 patients with wounds. Longer wound duration and unfavourable diagnoses were associated with a lower percentage of wound healing and a longer treatment time until healing.
Prof. Tomasz Banasiewicz, Head of Chair and Department of General, Endocrynological Surgery and Gastrointestinal Oncology, Poznan University of Medical Sciences
Bad wound or bad treatment? What can we do better?
The complex, difficult wounds require complex strategy of treatment. The single, simple solution does not exist, but the complexity of treatment is the only way to improve wound healing.
Denis Barritault, PhD President OTR3 and Emeritus, Professor at Paris Est Creteil University
How understanding the basis of tissue regeneration lead to CACIPLIQ spray as a wound healing agent to treat hard to heal wounds and improve patients’ quality of life.
Matrix therapy is a newly coined name to emphasis the importance of the extracellular matrix in regenerative medicine. Heparan sulfates (HS) are key elements of the extracellular matrix (ECM) scaffold which store and protect most growth factors/cytokines controlling the cell migration and differentiation required for healing processes. Tissue injury will lead to destruction of cells and surrounding ECM with resulting scars or fibroses. We have engineered biodegradable polymers (alpha 1-6 polyglucose carboxymethyl sulfate) mimicking (RGTA) to replace destroyed HS in the damaged ECM scaffolding and to protect cytokines produced by healthy neighboring cells, thereby restoring the ECM microenvironment and tissue homeostasis. This matrix therapy approach has considerably improved the quality of healing in various animal models with reduction or absence of fibrosis resulting in a regeneration process.
Ibby Younis, MBBCh, MRCS (ENG), MSc, FRCS (Plastic Surgeon)
Winning with Negative pressure wound therapy.
Two complex cases of advanced woundcure.
Drs. Nina (CA) Lansdorp, hyperbaric physician and PhD-student
Perianal Crohn’s disease and hyperbaric oxygen therapy.
Perianal wounds and fistulas are some of the most challenging complications of Crohn’s disease, with limited effects of currently available medical and surgical interventions. Hyperbaric oxygen therapy has been proposed as a possible new (adjuvant) treatment for these complications. During this presentation the possible beneficial effects will be discussed, from pathophysiologic mechanisms to the preliminary results of ongoing trials.
Capt. Surg. O. Boonstra, military trauma surgeon Royal Netherlands Navy
Bad, worse or worst treatment of massive soft tissue injuries in Afghanistan.
Emiel van Haren, MD
The Wound-Q: a New Patient-Reported Outcome Instrument for Chronic Wounds.
Our research team has developed a new PRO instrument to measure outcomes in patients with chronic wounds. The enormous burden on physical, psychological and social functions in chronic wound patients makes this instrument a clinical relevant tool to improve patient-centered care. Furthermore, the WOUND-Q will facilitate comparison of new products and devices that may improved the quality of life of such patients. It will also support comparison of providers, evaluation of best practices and continuous quality improvement.
This presentation will give you an overview how we developed this outcome measure.
Afsluiting door Christel de Laat